Side effects include: Immediate-release lamotrigine (the active ingredient contained in Lamictal CD ) as adjunctive anticonvulsant therapy in adults: dizziness, headache , diplopia, ataxia, nausea , blurred vision, somnolence, rhinitis, pharyngitis , rash.Serious long-term side effects that Lamictal can cause include: multiorgan hypersensitivity syndrome and organ failure hemophagocytic lymphohistiocytosis (a potentially fatal immune system reaction)Mar 18, 2023 · Abdominal or stomach pain (severe) blurred vision, aching, burning, or swollen eyes. chest pain. confusion. discomfort while urinating or frequent urination. fever. hallucinations or seeing, hearing, or feeling things that are not there. itching. mental depression or other mood or mental changes. Rarely, lurasidone can cause deadly symptoms. NMS can affect your heart, muscles, and kidneys. See your doctor right away if you get: A high fever. Stiff muscles. A change in your mood or behavior ... Side effects include: Immediate-release lamotrigine (the active ingredient contained in Lamictal CD ) as adjunctive anticonvulsant therapy in adults: dizziness, headache , diplopia, ataxia, nausea , blurred vision, somnolence, rhinitis, pharyngitis , rash.The most commonly observed side effects were dizziness, somnolence, diplopia, fatigue, nausea, vomiting, ataxia, abnormal vision, abdominal pain, tremor, dyspepsia, abnormal gait, headache, balance disorder, and asthenia. In clinical trials in children aged 1 month to 4 years, the most commonly reported side effect was somnolence.The most commonly observed side effects were dizziness, somnolence, diplopia, fatigue, nausea, vomiting, ataxia, abnormal vision, abdominal pain, tremor, dyspepsia, abnormal gait, headache, balance disorder, and asthenia. In clinical trials in children aged 1 month to 4 years, the most commonly reported side effect was somnolence.Jun 1, 2023 · Descriptions. Lamotrigine is used alone or together with other medicines to help control certain types of seizures (eg, partial seizures, tonic-clonic seizures, or Lennox-Gastaut syndrome) in the treatment of epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to take it. In uncontrolled, long-term schizophrenia trials, this drug was associated with a mean increase in glucose from baseline of 1.8 mg/dL at 24 weeks, 0.8 mg/dL at 36 weeks, and 2.3 mg/dL at 52 weeks. Similar results were observed in bipolar depression studies.Although ophthalmological testing was performed in 1 controlled clinical trial, the testing was inadequate to exclude subtle effects or injury occurring after long-term exposure. Moreover, the capacity of available tests to detect potentially adverse consequences, if any, of lamotrigine’s binding to melanin is unknown [see Clinical ... Results. Treatment efficacy was observed at week 4, with the improved HSDS scores sustained until week 52 for all types of BP; 50% of the patients with any type of BP could be treated with LTG for 1 year, whereas ~40% could be treated for >1.5 years. However, 25% of the patients were withdrawn within the first 4 weeks.For Anxiety "I have taken lamotrigine for years with no side effects. It takes approximately 1.5-2 months for lamotrigine to take full effect. Side effects are typically avoided by starting at very low doses (I started at 25 mg once a day) and slowly increasing the dose over time.Rarely, lurasidone can cause deadly symptoms. NMS can affect your heart, muscles, and kidneys. See your doctor right away if you get: A high fever. Stiff muscles. A change in your mood or behavior ...Oct 4, 2016 · That said, the side effects associated with lamotrigine may be more tolerable than side effects induced by other anxiolytic medications. As was already mentioned, lamotrigine does not appear to impair cognitive function and may even provide a modest boost in cognition. Additionally, long-term trials suggest that lamotrigine is a “weight ... Lamictal is rapidly absorbed and peak levels are reached within 1.7 to 4.8 hours of administration. The effects of Lamictal last for over 24 hours and once-daily dosing is often prescribed. However, some doctors prefer to split the dose to decrease the risk of side effects such as drowsiness. 7.For Anxiety "I have taken lamotrigine for years with no side effects. It takes approximately 1.5-2 months for lamotrigine to take full effect. Side effects are typically avoided by starting at very low doses (I started at 25 mg once a day) and slowly increasing the dose over time.The long-term consequences of this are unknown. Lamotrigine is known to affect sleep. ... In addition, lamotrigine shares few side effects with other, unrelated ...The phase IV clinical study analyzes which people take Lamotrigine and have Brain damage. It is created by eHealthMe based on reports of 61,601 people who have side effects when taking Lamotrigine from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions. Phase IV trials are used to detect ...Many short-term side effects subside after a few weeks (once your body has gotten used to the drug). Long-term: Some individuals may take the drug for an extended period of time and be tolerating it fine, and then notice side effects that become problematic after a year or two. Usually over the long term an individual has increased their dosage ...The clinical features of these psychiatric side effects are: affective switches, full acute psychotic episodes, and hallucinations. In conclusion, lamotrigine is an effective drug, very useful in the therapy of epilepsy and mood disorders, but clinicians have to be aware of the risk that it can induce psychiatric symptoms or acute episodes.To date, there are no known problems associated with long term use of lamotrigine. It is a safe and effective medication when used as directed. It is important to note that some of the side effects listed above (particularly rash and suicidal thoughts) may continue to occur or worsen if you continue taking the medication.Nov 5, 2019 · It’s used for long-term treatment of the more severe type of bipolar disorder, ... The more common side effects of Lamictal in people treated for bipolar I disorder include: nausea; Submitted by sportz_nut on Fri, 2009-05-01 - 16:46. I can't think of any long term for Lamictal, it has been my savior the past 8 years, as for Keppra, I don't know if it has and effect on the body, I do know that if your freind has trouble sleeping give them a Keppra, they should be out like a light. "My side effect from Keppra anyway". Fatigue. Nausea. Tremor. Rash. Weight gain. Most of these side effects lessen with time. Long-term effects vary from drug to drug. In general: Pregnant women should not take anticonvulsants ...Apr 8, 2021 · Although ophthalmological testing was performed in 1 controlled clinical trial, the testing was inadequate to exclude subtle effects or injury occurring after long-term exposure. Moreover, the capacity of available tests to detect potentially adverse consequences, if any, of lamotrigine's binding to melanin is unknown. Serious long-term side effects that Lamictal can cause include: multiorgan hypersensitivity syndrome and organ failure hemophagocytic lymphohistiocytosis (a potentially fatal immune system reaction)hoarseness. lack or loss of strength. pain in the lower back or side. swelling of the hands, feet, or lower legs. trembling or shaking. Common side effects that do require medical attention ...Abstract. Effective treatment of epilepsy depends on medication compliance across a lifetime, and studies indicate that drug tolerability is a significant limiting factor in medication maintenance. Available antiepileptic drugs (AEDs) have the potential to exert detrimental effects on cognitive function and therefore compromise patient wellbeing.Side effects include: Immediate-release lamotrigine (the active ingredient contained in Lamictal CD ) as adjunctive anticonvulsant therapy in adults: dizziness, headache , diplopia, ataxia, nausea , blurred vision, somnolence, rhinitis, pharyngitis , rash.Mar 18, 2023 · Abdominal or stomach pain (severe) blurred vision, aching, burning, or swollen eyes. chest pain. confusion. discomfort while urinating or frequent urination. fever. hallucinations or seeing, hearing, or feeling things that are not there. itching. mental depression or other mood or mental changes. Very common side effects of taking lamotrigine (affecting more than one in ten people) include: headaches; skin rashes; Common side effects of taking lamotrigine (affecting up to one in ten people) include: feeling aggressive, agitated or irritable; feeling sleepy, tired or drowsy; insomnia (having difficulty sleeping) feeling dizzy; shaking or ...Lamictal (lamotrigine) is a mood stabilizer and anticonvulsant prescribed to treat bipolar disorder and epilepsy. This medication can be used to reduce the occurrence of mood episodes in people with bipolar disorder and to control seizures in people with epilepsy. If people suddenly stop taking their medication, they may experience Lamictal ...Aug 29, 2023 · Long-Term Side Effects of Clonidine. There is the potential for a multitude of adverse effects involving the use of clonidine. People taking the substance may experience fever, headaches, fatigue, and general weakness. More serious effects on the cardiovascular system are also possible. These effects can include heart palpitations, congestive ... Lamotrigine (LTG) is a drug commonly used to treat epilepsy and can also be used to manage mood disorders, such as bipolar disorder. One of the most dangerous adverse effects of LTG is skin rash, which can make early cessation necessary. Here, we examine the adverse effects associated with long-term use of LTG for the treatment of mood disorders.Geriatric Although appropriate studies on the relationship of age to the effects of lamotrigine have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of lamotrigine in the elderly.4. Narcotic painkillers . 5. Sleeping aids . 6. Incontinence drugs . 7. Antihistamines (first generation) How they can affect memory: Benzodiazepines dampen activity in key parts of the brain, including those involved in the transfer of events from short-term to long-term memory.Summary. Common side effects of Lamictal ODT include: ataxia, skin rash, headache, insomnia, and nausea. Other side effects include: infection, dyspepsia, abnormal gait, constipation, and drowsiness. Continue reading for a comprehensive list of adverse effects. Applies to lamotrigine: oral tablets conventional, oral tablets extended-release ...multiple swollen and inflamed skin lesions. muscle pain or stiffness. muscle tension or tightness. normal menstrual bleeding occurring earlier, possibly lasting longer than expected. numbness of the feet, hands and around mouth. pains in the stomach, side, or abdomen, possibly radiating to the back.Lamotrigine and sleep issues tend to go hand-in-hand according to some scientific reports. Of course, this doesn’t mean everyone using Lamictal will automatically have insomnia. Today we’re going to look into the main Lamotrigine side effects and how it affects your sleep. Finding the right medication for any ailment is often a complicated ...At first I was just on abilify— a pretty high dose— and while it kept me free from hypomania, it didn’t really do much for the depression. Lamictal, on the other hand, has worked wonders in that respect. Very little side effects— I wake up nauseous but it fades after about an hour, and it’s definitely worth it.Many short-term side effects subside after a few weeks (once your body has gotten used to the drug). Long-term: Some individuals may take the drug for an extended period of time and be tolerating it fine, and then notice side effects that become problematic after a year or two. Usually over the long term an individual has increased their dosage ...Apr 8, 2021 · Although ophthalmological testing was performed in 1 controlled clinical trial, the testing was inadequate to exclude subtle effects or injury occurring after long-term exposure. Moreover, the capacity of available tests to detect potentially adverse consequences, if any, of lamotrigine's binding to melanin is unknown. Mar 20, 2023 · In 2 longer-term trials, the mean change in blood glucose from baseline in patients treated with this drug (mean exposure 213 days; n=646) was 5 mg/dL (vs. placebo -0.05 mg/dL). Among patients with major depressive disorder receiving the extended-release formulation of this drug, a FBG greater than 126 mg/dL occurred in 7%, 12%, and 6% of those ... Lamictal (lamotrigine) is a mood stabilizer and anticonvulsant prescribed to treat bipolar disorder and epilepsy. This medication can be used to reduce the occurrence of mood episodes in people with bipolar disorder and to control seizures in people with epilepsy. If people suddenly stop taking their medication, they may experience Lamictal ...Yes each time Lamictal dose increased mildly 10 days later unsteady and stumbling when walking. Loss of appetite and weight. Epilepsy expert Dr Lu in Rochester NY gradually decreased Lamictal and gradually put on Topamax seizure med. Have remained on low dose of each for years seizure and problem free.Oct 26, 2022 · These include dizziness, headache, and nausea. Other Lamictal side effects are rare but more serious. These include rash, low blood cell levels, and an increase in suicidal thoughts and behaviors. Lamictal has a boxed warning for serious, life-threatening rash. Feeling poorly. Fever. Itching skin. Hives. Red blisters on areas of the body, which may include the face or mouth. Symptoms of a more serious rash can include peeling skin, painful blisters, inflammation of the eyes, swollen lymph nodes, and flu-like symptoms. The symptoms can range from benign to potentially fatal.The initial use of lamotrigine was to treat people with depressed, manic and mixed states that did not respond to existing medications. Some patients are now being maintained on lamotrigine on a long term basis in an attempt to prevent future episodes. Evidence regarding the effectiveness of lamotrigine as a long-term prophylactic agent is ...55. 9 yr. ago. 🏕️⛺. I started taking Lamictal earlier this year and am currently taking 200 mg daily. Memory loss was one of the first side effects I noticed. It's very frustrating, but Lamictal is really helping me so I continue to take it. I wonder what the long term effects will be. I'm paranoid about getting Alzheimers when I'm older ...Apr 25, 2018 · lamotrigine (Lamictal) for seizures and bipolar disorder can cause a rare but very serious reaction that excessively activates the body’s infection-fighting immune system. This can cause severe multiple swollen and inflamed skin lesions. muscle pain or stiffness. muscle tension or tightness. normal menstrual bleeding occurring earlier, possibly lasting longer than expected. numbness of the feet, hands and around mouth. pains in the stomach, side, or abdomen, possibly radiating to the back.Add Gift Card. Check Gift Card status and balance. Our major shipping carriers have informed us to expect temporary service disruptions due to COVID-19 impacts & natural weather situations across the U.S. As a result, shipments may experience delays. Cart (6) Price. 5HSSLD21159-DPIBLUE-OS. SKU.Jan 24, 2016 · Mood or behavior changes, such as depression, anxiety, agitation, hostility, restlessness, mental or physical hyperactivity, suicidal thoughts. Common side effects of lamotrigine that are not emergencies but should also be reported to your doctor include: Headache or dizziness. Blurred or double vision. Dry mouth. The phase IV clinical study analyzes which people take Lamotrigine and have Brain damage. It is created by eHealthMe based on reports of 61,601 people who have side effects when taking Lamotrigine from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions. Phase IV trials are used to detect ...Sep 13, 2021 · For Healthcare Professionals General. The more commonly reported adverse reactions have included dizziness, headache, diplopia, ataxia, nausea,... Immunologic. In cases of hemophagocytic lymphohistiocytosis (HLH), patients have presented with signs of systemic... Hypersensitivity. Nervous system. ... May 20, 2022 · Many people can take lamotrigine safely for several months or years. But there are some side effects that might happen over a long time. Long-term treatment with lamotrigine can cause osteoporosis and osteopenia, increasing your risk of breaking a bone. Your doctor can arrange for tests to check your bone strength. Lamictal is available in generic form as lamotrigine. Lamotrigine, also known as Lamictal, is a medication used to treat several different types of seizures. Typically, it is used as an add-on medicine for adults whose partial seizures are not well controlled by another seizure medicine. Learn about Lamotrigine’s usage, side effects, and ...stomach pain and cramps. swelling of the face, fingers, feet, or lower legs. trouble breathing. twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs. unpleasant breath odor. vomiting of blood. watery or bloody diarrhea. weight gain. yellow eyes or skin.Serious long-term side effects that Lamictal can cause include: multiorgan hypersensitivity syndrome and organ failure hemophagocytic lymphohistiocytosis (a potentially fatal immune system reaction)At first I was just on abilify— a pretty high dose— and while it kept me free from hypomania, it didn’t really do much for the depression. Lamictal, on the other hand, has worked wonders in that respect. Very little side effects— I wake up nauseous but it fades after about an hour, and it’s definitely worth it. Mar 31, 2023 · Lamotrigine is rapidly absorbed and peak levels are reached within 1.5 to 4.8 hours of administration. The effects of lamotrigine last for over 24 hours, and once-daily dosing is often prescribed. However, some doctors prefer to split the dose to decrease the risk of side effects such as drowsiness. 7. Descriptions. Quetiapine is used alone or together with other medicines to treat bipolar disorder (depressive and manic episodes) and schizophrenia. Quetiapine extended-release tablet is also used together with other antidepressants to treat major depressive disorder. This medicine should not be used to treat behavioral problems in older adult ...The typical starting dosage is 0.01 to 0.03 milligrams per kilogram (mg/kg) of body weight per day. This is divided into two or three doses per day. Your child’s doctor can determine the right ...redness of the face, neck, arms and occasionally, upper chest. shakiness and unsteady walk. sudden death. trouble concentrating. trouble sleeping. unconsciousness. unsteadiness, trembling, or other problems with muscle control or coordination. unusual paleness. Some side effects may occur that usually do not need medical attention.About lamotrigine Who can and cannot take it How and when to take it Side effects Pregnancy, breastfeeding and fertility Taking lamotrigine with other medicines and herbal supplements Common questions Although ophthalmological testing was performed in 1 controlled clinical trial, the testing was inadequate to exclude subtle effects or injury occurring after long-term exposure. Moreover, the capacity of available tests to detect potentially adverse consequences, if any, of lamotrigine’s binding to melanin is unknown [see Clinical ... Add Gift Card. Check Gift Card status and balance. Our major shipping carriers have informed us to expect temporary service disruptions due to COVID-19 impacts & natural weather situations across the U.S. As a result, shipments may experience delays. Cart (6) Price. 5HSSLD21159-DPIBLUE-OS. SKU. Lamotrigine can also cause other side effects. More common side effects. The more common side effects that can occur with use of lamotrigine include: dizziness; drowsiness; headache; double vision ...Common side effects of Depakote include: abdominal pain, asthenia, dizziness, drowsiness, nausea, and anorexia. Other side effects include: abnormality in thinking, alopecia, ataxia, nystagmus disorder, tremor, weight loss, fever, and skin rash. Continue reading for a comprehensive list of adverse effects. Applies to divalproex sodium: oral ...The most commonly observed side effects were dizziness, somnolence, diplopia, fatigue, nausea, vomiting, ataxia, abnormal vision, abdominal pain, tremor, dyspepsia, abnormal gait, headache, balance disorder, and asthenia. In clinical trials in children aged 1 month to 4 years, the most commonly reported side effect was somnolence.Geriatric Although appropriate studies on the relationship of age to the effects of lamotrigine have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of lamotrigine in the elderly.Continue to take lamotrigine even if you feel well. Do not stop taking lamotrigine without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. Your doctor will probably decrease your dose gradually. If you suddenly stop taking lamotrigine, you may experience seizures.For Anxiety "I have taken lamotrigine for years with no side effects. It takes approximately 1.5-2 months for lamotrigine to take full effect. Side effects are typically avoided by starting at very low doses (I started at 25 mg once a day) and slowly increasing the dose over time.To date, there are no known problems associated with long term use of lamotrigine. It is a safe and effective medication when used as directed. It is important to note that some of the side effects listed above (particularly rash and suicidal thoughts) may continue to occur or worsen if you continue taking the medication. Breastfeeding while taking lamotrigine: Lamotrigine can get into breast milk. Lamotrigine then gets into the baby’s body if they are breastfeeding, often at levels that are similar to the parent’s levels. Most infants who are breastfed by someone taking lamotrigine are not expected to have side effects. However, there have been case reports ...Lamotrigine (LTG) is a drug commonly used to treat epilepsy and can also be used to manage mood disorders, such as bipolar disorder. One of the most dangerous adverse effects of LTG is skin rash, which can make early cessation necessary. Here, we examine the adverse effects associated with long-term use of LTG for the treatment of mood disorders.Aug 1, 2023 · dryness of the mouth. feeling of warmth and redness of the face, neck, arms, and occasionally chest. heartburn. increased sweating. increased urination. itching of the vagina. trouble sleeping. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. For Healthcare Professionals General. The more commonly reported adverse reactions have included dizziness, headache, diplopia, ataxia, nausea,... Immunologic. In cases of hemophagocytic lymphohistiocytosis (HLH), patients have presented with signs of systemic... Hypersensitivity. Nervous system. ...multiple swollen and inflamed skin lesions. muscle pain or stiffness. muscle tension or tightness. normal menstrual bleeding occurring earlier, possibly lasting longer than expected. numbness of the feet, hands and around mouth. pains in the stomach, side, or abdomen, possibly radiating to the back.The initial use of lamotrigine was to treat people with depressed, manic and mixed states that did not respond to existing medications. Some patients are now being maintained on lamotrigine on a long term basis in an attempt to prevent future episodes. Evidence regarding the effectiveness of lamotrigine as a long-term prophylactic agent is ...Lamictal rash is a possible side effect of the medication lamotrigine, which is sold under the brand name Lamictal. It can be a mild rash or a more serious rash as a result of Stevens-Johnson syndrome or toxic epidermal necrolysis. It is important to contact your doctor as soon as you experience any side effects of Lamictal, including a rash.Lamotrigine is rapidly absorbed and peak levels are reached within 1.5 to 4.8 hours of administration. The effects of lamotrigine last for over 24 hours, and once-daily dosing is often prescribed. However, some doctors prefer to split the dose to decrease the risk of side effects such as drowsiness. 7.Nov 5, 2019 · It’s used for long-term treatment of the more severe type of bipolar disorder, ... The more common side effects of Lamictal in people treated for bipolar I disorder include: nausea; The safety of using Lamictal during pregnancy has not been established. Lamictal is secreted into breast milk, and breastfeeding while taking Lamictal is not recommended. Our Lamictal Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Rarely, lurasidone can cause deadly symptoms. NMS can affect your heart, muscles, and kidneys. See your doctor right away if you get: A high fever. Stiff muscles. A change in your mood or behavior ... For example, it is known that side effects like: ataxia, blurred vision, double vision, dizziness, nausea, and vomiting – are substantially more likely to occur among persons taking Lamictal at dosages of 500 mg per day – compared to persons taking Lamictal at dosages of 300 mg per day.Jun 9, 2007 · redness of the face, neck, arms and occasionally, upper chest. shakiness and unsteady walk. sudden death. trouble concentrating. trouble sleeping. unconsciousness. unsteadiness, trembling, or other problems with muscle control or coordination. unusual paleness. Some side effects may occur that usually do not need medical attention.
Long Term Effects for Lamotrigine. Sun, 08/21/2016 - 14:16. Topic: Living With Epilepsy - Adults. I have been on Lamotrigine for the past year at 300MG per day. I have started to experience major mood swings, headaches and dizziness, anger problems as well as memory and attention issues. I'm starting to look into the long term effects of this ... . Stevenson
dryness of the mouth. feeling of warmth and redness of the face, neck, arms, and occasionally chest. heartburn. increased sweating. increased urination. itching of the vagina. trouble sleeping. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.Mar 18, 2023 · Abdominal or stomach pain (severe) blurred vision, aching, burning, or swollen eyes. chest pain. confusion. discomfort while urinating or frequent urination. fever. hallucinations or seeing, hearing, or feeling things that are not there. itching. mental depression or other mood or mental changes. The initial use of lamotrigine was to treat people with depressed, manic and mixed states that did not respond to existing medications. Some patients are now being maintained on lamotrigine on a long term basis in an attempt to prevent future episodes. Evidence regarding the effectiveness of lamotrigine as a long-term prophylactic agent is ... Traditional AEDs such as valproate and enzyme-inducing AEDs (EIAEDs) may produce high incidences of decreased libido. Recently, sexual function changes related to new AEDs have been reported. Topiramate, pregabalin and gabapentin may cause SD, whereas oxcarbazepine, lamotrigine and levetiracetam may improve sexual function. The initial use of lamotrigine was to treat people with depressed, manic and mixed states that did not respond to existing medications. Some patients are now being maintained on lamotrigine on a long term basis in an attempt to prevent future episodes. Evidence regarding the effectiveness of lamotrigine as a long-term prophylactic agent is ...Common (1% to 10%): Arthralgia, blood creatinine phosphokinase increased/creatine phosphokinase increased, muscle rigidity, muscle spasms, muscle twitching, musculoskeletal stiffness, myalgia, pain in extremity. Uncommon (0.1% to 1%): Mobility decreased, muscle tightness, muscular weakness, musculoskeletal rigidity.It’s used for long-term treatment of the more severe type of bipolar disorder, ... The more common side effects of Lamictal in people treated for bipolar I disorder include: nausea;Apr 14, 2021 · Lamotrigine can also cause other side effects. More common side effects. The more common side effects that can occur with use of lamotrigine include: dizziness; drowsiness; headache; double vision ... Mar 18, 2023 · Abdominal or stomach pain (severe) blurred vision, aching, burning, or swollen eyes. chest pain. confusion. discomfort while urinating or frequent urination. fever. hallucinations or seeing, hearing, or feeling things that are not there. itching. mental depression or other mood or mental changes. Lamotrigine (LTG) is a drug commonly used to treat epilepsy and can also be used to manage mood disorders, such as bipolar disorder. One of the most dangerous adverse effects of LTG is skin rash, which can make early cessation necessary. Here, we examine the adverse effects associated with long-term use of LTG for the treatment of mood disorders.May 20, 2022 · Many people can take lamotrigine safely for several months or years. But there are some side effects that might happen over a long time. Long-term treatment with lamotrigine can cause osteoporosis and osteopenia, increasing your risk of breaking a bone. Your doctor can arrange for tests to check your bone strength. hoarseness. lack or loss of strength. pain in the lower back or side. swelling of the hands, feet, or lower legs. trembling or shaking. Common side effects that do require medical attention ....